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Archive for the ‘Nutrition and Health’ Category

Hyun Park Kang, co-author of a recent article in the Journal of Plant Registrations, punching leaf samples for DNA marker genotyping. Photo by Bao-Lam Huynh.

Commercial markets are embracing traditionally ethnic vegetable crops, adding diversity to the food system. Long beans (Vigna unguiculata subsp. sesquipedalis), which originated in Africa and have been refined through domestication in Southeast Asia, have an export value of $80 million. The edible pods are a symbol of luck and longevity, but more importantly, they pack a nutritious punch, offering a new food option, enriched in protein, vitamins, and minerals.

Despite these benefits, long beans have not broken into larger commercial markets because the current varieties require frequent applications of synthetic chemicals to manage aphids and root‐knot nematodes, limiting marketability and opening the potential of pest resistance. Concerns with pesticide applications have affected consumer demand, and the acreage of long bean has been in decline.

A recent article in the Journal of Plant Registrations (https://doi.org/10.1002/plr2.20361) details the development by researchers at the University of California–Riverside of new long bean germplasm lines that resist aphids and nematodes.

“We are confident that once consumers become familiar with the new resistant varieties, the crop will gain momentum,” says Bao‐Lam Huynh, assistant professor in the Department of Nematology at the University of California–Riverside and first author on the paper.

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T cells are positioned at the frontline of the body’s immune system to fight infection, cancer, and autoimmune disease. While different subtypes of T cells exist, how these cells take their different forms has remained elusive. 

Now, a multi-institutional team of researchers led by Yale School of Medicine (YSM) has added clarity to the complex, dynamic molecular interactions that occur in the human immune system. In a new study, the researchers have identified one of the levers that controls the fate of T cells and what subtype they transform into. Their findings were published recently in the journal Science.

“Researchers often think of T cells as falling into different buckets—T cells for infection or T cells for cancer or autoimmunity,” said Nikhil Joshi, PhD, associate professor of immunology at YSM and senior author of the study. “We want to have a more holistic view of this process. T cells all start at the same place, and we wanted to understand the rules that control how T cells change in response to the molecular signals they see as they mount a defense.”

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FIG. 1. Paste made from avocado flesh in a lab-scale malaxer where the oil droplets start to coalescence before oil extraction. Credit: John Almazan

Avocadoes are having a moment. The nutritional benefits promote heart health and reduce inflammation, blood pressure, and cholesterol. Not to mention the popularity of avocado toast.

Despite the rise in consumer interest, there are no standards to define the chemical and physical characteristics of avocado oil. Without an internationally defined standard, consumers are left vulnerable to adulterated or fraudulent avocado oil in the marketplace.

“Currently selling and buying avocado oil is like playing a boardgame with no rules,” said Selina Wang, department vice-chair and associate professor of Cooperative Extension in the Department of Food Science and Technology at the University of California, Davis. “With no enforceable standards in place, cheaters win and honest players get taken advantage of.”

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Humans have evolved to eat a variety of foods. No one component is entirely bad or entirely good. Many diets popular today, approach nutrition through a narrow, simplified lens. Every decade one component of our diet is placed center stage as the villain that is responsible for all of our woes. In recent decades, the spotlight has been turned on fats.

Fat is essential, providing a source of energy and a feeling of satiety. There are essential fatty acids that humans cannot produce, including linoleic acid (omega- 6) and alpha-linolenic acid (omega-3). Both fatty acids are obtained from the food we eat and play a critical role in major cellular events, including metabolism, inflammation, cell differentiation, and cell death. Some dietitians and nutritionists have advocated for eating an equal amount of omega-6 and omega-3 fatty acids, resulting in a 1:1 ratio. This diet is presumed to mimic the ancient human diet, though no definitive data supports what early humans actually ate consistently. The modern American diet ranges from a value of 10:1 to 15:1.

The overarching nutritional message has been that the modern diet suffers from an “omega imbalance.” The imbalance is a ‘concern,’ because omega-6 fatty acids, which skews the index to higher numbers, have been assumed to promote poor health outcomes and disease, including increased ‘bad’ cholesterol (LDL), inflammation, and coronary heart disease. Surprisingly, no randomized controlled clinical trials actually support any of these claims.

The concept of the omega-6:omega-3 ratio is “flawed and unhelpful,” says William Harris, professor of basic biomedical sciences at the University of South Dakota, in Vermillion, South Dakota, USA.

Harris is the founder and president of the Fatty Acid Research Institute, a non-profit research and education organization created to further the study of fatty acids and disease. To expand on Harris’s point, measuring the ratio is difficult because each fatty acid appears as various species in different ratios in different reservoirs in the body. According to Harris, this simple metric has “both theoretical and practical complications” that create fundamental misunderstandings that have cascaded through the field. He has published numerous articles describing the lack of scientific validation to support using this ratio as an indicator of healthful diet.

Martha Belury, Carol S. Kennedy professor of human nutrition in the Department of Human Sciences at the Ohio State University, Columbus, Ohio, USA, concurs with Harris’s assessment. She believes it is time to move away from the omega-6:omega-3 ratio and re-evaluate the benefits of the much maligned omega-6 fat.

“Science and health are short-changed if we oversimplify,” said Belury. “While omega-3 has an important role in health, omega-6 has a pivotal role to play as well. This is an important message for consumers and practitioners.”

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