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Archive for February, 2019

Researchers show compounds based on chloroindazole reduce inflammation as well as promote neuroprotection and remyelination, improving the primary symptoms in a mouse model of multiple sclerosis

Multiple sclerosis is an autoimmune disease that affects more than 2.3 million people worldwide. This debilitating condition periodically shutters communication between the brain and other parts of the body, resulting in symptoms that range from numbness and tingling in the arms and legs to blindness and paralysis. While treatments are available to alleviate inflammation, no therapies exist to protect neurons or repair the degraded myelin sheath that normally surrounds nerves.

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Scientists unlock new molecular secrets to unravel the mystery to how a neuron obtains an axon. 

Neurons transfer information through electrical impulses. These impulses travel down the long, threadlike axon that extends from the neuron’s central body. At the end of the axon, the impulse arcs across a gap to the fingerlike dendrite of the neighboring neuron. This spark of a synapse conveys information from one neural cell to the next. The complex neural circuit enables every action, emotion, and thought you experience every day.

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